A crowd of about 1,000 people marched through Cairo on Sunday, demanding the resignation of President Abdel Fattah al-Sisi and a reinstatement of the death penalty.
A group of protesters, including some wearing masks, threw stones and set tyres on fire as the demonstration reached the capital’s Tahrir Square.
The protesters also threw a rock at police, who responded with tear gas and water cannon.
The protests came after the military-backed government ousted Sisi in a military coup last year and brought a new wave of protests.
The government also launched a crackdown on civil society.
“The protesters were peaceful, but we do not accept their demands,” said Abdel Hamid El-Beltagy, a spokesman for the Egyptian Centre for Human Rights.
“We will not accept the regime’s violence.”
Al Jazeera’s Nabeel Rajab in Cairo contributed to this report.